Dr Casalotti has investigated receptors systems (GABAa, Peripheral Benzodiazepine, NMDA, Opiate) at the protein and gene expression level, and studied the role of gap junctions in the auditory system. Currently his lab focuses on the cellular and molecular mechanisms that are affected by ethanol (alcohol) consumption.
The laboratory uses the Drosophila (fruit fly) model to study ethanol-induced behavioural changes including tolerance, preference and relapse. Cellular and molecular changes caused by alcohol consumption are analysed in both normal and genetically modified flies with the aim of understanding mechanisms that could play a role in human alcohol addiction.
Dr Casalotti is an honorary lecturer at UEL and director of BiosearLab, a Community Interest Company (CIC) based at UEL, focussed on promoting research collaborations with external organisations while providing training opportunities for UEL graduates.